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Medicine Oral Health Research Periodontics

Does local simvastatin-alendronate conjugate prevent periodontitis bone loss?

This summary is based on the article published in the Journal of Periodontal Research: Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss (October 2013)


Local host-modulation therapy is an emerging approach to prevent disease progression in sites with moderate periodontitis. The combination of simvastatin and alendronate would be an intriguing host-modulatory strategy because of the bone-anabolic properties of simvastatin and the antiresorptive/bone-targeting characteristics of alendronate.

Purpose of the Study

The objective of this study is to evaluate the effects of local administration of a simvastatin–alendronate–β-cyclodextrin (SIM–ALN–CD) conjugate for preventing experimental periodontitis bone loss.

Key Message

Locally applied SIM–ALN–CD has the potential to prevent episodes of periodontitis bone loss.


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