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CE Showcase Supporting Your Practice

The Concept of Smart Tissue Regeneration with PRF

In this presentation, Dr. Richard Miron gives Oasis Discussions’ viewers an overview on the use of platelet-rich fibrin (PRF) in regenerative dentistry.

  • For those that would like to learn more about PRF in a full day hands on workshop, you can learn more and register at www.prfedu.com 
  • Canadian dentists apply code CDA-Oasis to receive a $150 discount on your registration


Blood contains various (~150) growth factors such as BMP (bone morphongenetic proteins), FGF (fibroblast grown factor), PDGF (platelet derived growth factor), IGF (insulin like growth factor) as well as VEGF (vascular endothelial growth factor) and each has a specific function.

The platelet concentrate technique requires centrifugation of the blood to separate components which transiently increases platelet and leucocyte counts as much as 6-8-fold. For PRF, blood is drawn without the use of an anticoagulant as anticoagulant use inhibits wound healing. PRF is composed of platelets, leucocytes as fibrin. Fibrin plays a major role as it slowly releases cytokines and plays a major role in cell migration while it acts a provisional scaffold or matrix. This optimizes tissue regeneration. White cells also play an important role in PRF as they improve osteogenesis and angiogenesis.

At times, PRF can be used alone but, it may need to be used in conjunction with other materials for different uses (eg. connective tissue graft + PRF in the absence of keratinized tissue for soft tissue management).

Clinical Indications for PRF

  • Socket preservation
  • Root coverage
  • Soft tissue management
  • Sinus lifts
  • Immediate loading
  • Bone grafts
  • Facial esthetics/cosmetology
  • Orthopaedics – fractures and wound healing
  • vascularization


The Concept of Smart Tissue Regeneration with PRF (25 mins)


The Concept of Smart Tissue Regeneration with PRF (41 mins)


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