Does local simvastatin-alendronate conjugate prevent periodontitis bone loss?
This summary is based on the article published in the Journal of Periodontal Research: Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss (October 2013)
Local host-modulation therapy is an emerging approach to prevent disease progression in sites with moderate periodontitis. The combination of simvastatin and alendronate would be an intriguing host-modulatory strategy because of the bone-anabolic properties of simvastatin and the antiresorptive/bone-targeting characteristics of alendronate.
Purpose of the Study
The objective of this study is to evaluate the effects of local administration of a simvastatin–alendronate–β-cyclodextrin (SIM–ALN–CD) conjugate for preventing experimental periodontitis bone loss.
Locally applied SIM–ALN–CD has the potential to prevent episodes of periodontitis bone loss.
Do you have any particular question on this topic? Do you have any comments or suggestions? Email us at email@example.com
You are invited to comment on this post and provide further insights by posting in the comment box which you will find by clicking on “Post a reply“ below. You are welcome to remain anonymous and your email address will not be posted.