How safe are benzodiazepines?
This summary is based on the Rapid Response Report developed by the Canadian Agency for Drugs and Technologies in Health: High dose and watchful dosing of benzodiazepines: a review of the safety and guidelines
- No “watchful dose” for benzodiazepines was identified.
- Benzodiazepines may be used in higher than 10 mg diazepam-equivalent doses in some circumstances, but data were limited.
- What is the clinical evidence for safety of high-dose (>10 mg diazepam equivalent) benzodiazepine use?
- What is the clinical evidence regarding the safety of different watchful doses of benzodiazepines?
- What are the evidence-based guidelines regarding watchful dosing or high-dose of benzdiazepines?
The JCDA Oasis Team is collaborating with the Canadian Agency for Drugs and Technologies in Health to provide you with the latest clinical information.
Do you need further information related to this subject? Do you have any comments or suggestions? Email us at oasisdiscussions@cda-adc.ca
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The pro-drug of benzodiazepine first pass metabolism can influence the bio-availability, induced by enzyme CYP3A4.
M. Sc. Pharm. D