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Oral Health Research Periodontics

Is there evidence for the periodontal-systemic association?

In a Special Issue (April 2013), the Journal of Clinical Periodontology presented a series of articles that explored the association between periodontitis and some systemic diseases. The following is a summary of the article: Periodontal systemic association: review of the evidence


The review aims to critically appraise recent research on the associations between periodontal disease and systemic diseases and conditions, specifically respiratory disease, chronic kidney disease, rheumatoid arthritis, cognitive impairment, obesity, metabolic syndrome, and cancer.

Key Messages

  • There was substantial heterogeneity in the definitions used to identify periodontitis and very few studies met a stringent threshold for periodontitis.
  • There is a need to reach a consensus on what constitutes periodontitis for future studies of putative associations with systemic diseases.
  • Published evidence supports modest associations between periodontitis and some, although not all, of the diseases and conditions reviewed. 


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