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Oral Medicine Restorative Dentistry

What is the etiology of tooth dysplasias?

This video presentation (31.43) is available through the School of Dentistry at the University of Michigan

This video is presented by Dr. James P. Simmer, DDS, PhD, Professor in the Department of Biologic and Material Sciences at the University of Michigan

Defects arising during tooth development

  • Environment/systemic disturbance
    • Enamel hypoplasia (fever)
    • Fluorosis, Tetracycline staining
  • Genetic
    • Limited to teeth (non-syndromic)
      • Dentinogenesis imperfecta
      • Amelogenesis impeerfecta
    • Affecting other parts of the body
      • Osteogenesis imperfecta
      • Syndromic amelogenesis imperfecta

Key Messages

  • Genetic consultation: improvements in DNA sequencing will allow whole exome or whole genome sequencing to identify mutations likely to cause the disease. 
  • Defining the genetic etiology is the ultimate diagnosis.

Watch the video


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