This question was submitted by a general dentist: Is it safe to use vasoconstrictors in patients with sickle-cell disease? Which one is the best choice? Could I perform a painless dental extraction without vasoconstrictors in these cases? Dr. George Sandor, DDS MD and Dr. Suham Alexander, Oasis Clinical Editor provided this initial response. Sickle Cell Anemia  … Continue reading Is it safe to use vasoconstrictors in patients with sickle-cell disease?