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Pharmacology

What are the expected benefits and potential harms of bisphosphonates for the treatment of osteoporosis?

This summary is based on the article published in the Canadian Family Physician journal: Bisphosphonates for treatment of osteoporosis. Expected benefits, potential harms, and drug holidays. A Clinical review. (April 2014) Jacques P. Brown MD; Suzanne Morin MD MSc; William Leslie MD; Alexandra Papaioannou MD; Angela M. Cheung MD PhD; Kenneth S. Davison PhD; David Goltzman MD; David Arthur Hanley MD; Anthony Hodsman MD; Robert Josse MD; Algis Jovaisas MD; Angela Juby MD; Stephanie Kaiser MD; Andrew Karaplis MD; David Kendler MD; Aliya Khan MD; Daniel Ngui MD; Wojciech Olszynski MD PhD; Louis-Georges Ste-Marie MD; and Jonathan Adachi MD Context  ...

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Does the sugar found in medications increase the risk of caries?

This summary is based on the article published in the Journal of the American Dental Association: Sugar content, cariogenicity, and dental concerns with commonly used medications (February 2015) Mark Donaldson, BSP, RPH, PharmD, FASHP, FACHE Jason H. Goodchild, DMD Joel B. Epstein, DMD, MSD, FRCD(C), FDS, RCS(Edin) Courtesy of the American Dental Association, you can access the full-text article for the next 3 months here (PDF) Context Oral adverse events such as cariogenicity are often overlooked as drug-associated effects because the sugar content of many medications may be negligible compared with the patients’ overall dietary intake of sugar. There are, ...

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Oasis Patient Resource: Dry Mouth

The Oasis Patient Resource is a series of tools that help dentists explain basic dental concepts and procedures to their patients. This video and additional materials are provided to dentists to use for patient information. If you are interested in using the video in your own practice, please email us at oasisdiscussions@cda-adc.ca and we will gladly provide you with the original Powerpoint presentation as well as the video file. You will then be able to customize it with your own logo and office information.  Download this Oasis Patient Resource: Dry Mouth (PDF)  Download the original Dry Mouth Pamphlet (PDF) Watch the video  Please note that you ...

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Dealing with systemic diseases in the elderly patient

This summary is based on the article published in Dental Clinics of North America: Systemic Diseases and Oral Health (October 2014) Mary Tavares, DMD, MPH; Kari A. Lindefjeld Calabi, DMD; Laura San Martin, DDS, PhD, MDPH           Context Inflammation has been recognized as the key factor that connects oral diseases and systemic chronic diseases. 1 Chronic diseases are defined as long-lasting illnesses, with duration of more than 3 months that affect a person’s life and require constant medical treatment. The complexity of dental treatment in the elderly is greater because of the effects of these chronic diseases, ...

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What are the oral implications of polypharmacy in the elderly?

This summary is based on the article published in Dental Clinics of North America: Oral Implications of Polypharmacy in the Elderly (October 2014) Mabi L. Singh, DMD, MS; Athena Papas, DMD, PhD       Context There are age-related changes in the systems of the body, which alter the pharmacokinetics and pharmacodynamics of medications and make the elderly more vulnerable to adverse events. A major side effects of medications is the qualitative and quantitative change the cause in saliva (salivary hypofunction), by their anticholinergic effects. With salivary hypofunction, a plethora of complications arise, resulting in decreased quality of life in the ...

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Is octenidine hydrochloride available and/or recommended as an oral rinse agent?

This question was submtted by general dentist: Since Octenidine Hydrochloride seems better than Chlorhexidine, is it available and/or recommended as an oral rinse agent?  Under what name can it be purchased? Drs. Archie McNicol and Suham Alexander provided this quick initial response.   Antiseptic mouth rinses are used clinically to improve dental health and/or to prevent infections arising from oral pathogens. Antimicrobial mouth rinses target predominantly Streptococcus mutans.  Octenidine hydrochloride (Octenisept) belongs to a class of chemicals called bispyridinamines and was initially developed for use as a topical antimicrobial agent. It is capable of forming complexes and adhering to whole cells ...

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What is the placebo effect on burning mouth syndrome? A review

This summary is based on the article published in Oral Diseases: Placebo effect in burning mouth syndrome: a systematic review (April 2014) M Kuten-Shorrer, JM Kelley, ST Sonis, NS Treister     Context Burning mouth syndrome (BMS), also referred to as stomatodynia, is a chronic pain condition that manifests as a burning dysesthesia in the oral cavity, generally localized to the tongue, but that also frequently affects the inner aspect of the lips and the anterior hard palate. 1 BMS is defined by the absence of any local or systemic causes such as candidiasis, hyposalivation, nutritional deficiencies, or uncontrolled diabetes. ...

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Audio Interview: Researchers at the University of Calgary unlock a new mechanism in pain management

Dr. Chiraz Guessaier, CDA Oasis Project Manager, spoke with Dr. Gerald Zamponi, Neuroscientist, Professor, and Senior Associate Dean of Research in the Faculty of Medicine at the University of Calgary. Dr. Zamponi and his team unlocked a new mechanism in pain management by means of which chronic pain can be reversed.       Listen to the audio interview http://www.oasisdiscussions.ca/wp-content/uploads/2014/09/Zamponi_Original.mp3   View Dr. Gerald Zamponi profile Visit the Hotchkiss Brain Institute website  

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