Antimicrobial Dental Material for Bacterial Inhibition and Caries Reduction
Dr. Kimberly Ngai is a third-year student in pediatric dentistry in the Faculty of Dentistry at the University of Toronto. She met Dr. John O'Keefe at the most recent meeting of the Canadian Academy of Pediatric Dentistry in September 2019. Dr. Ngai presented her research project and won first place in the graduate research competition.
She joins Dr. O'Keefe to tell him about her research project and its impact on clinical dentistry.
Dr. Kimberly Ngai is a third year graduate student in the pediatric dentistry program at the University of Toronto. She completed her dental training at the University of Western Ontario in London, Ontario, in 2016, followed by a pediatric general practice residency at the IWK Health Centre in Halifax, Nova Scotia.
- The project aimed at evaluating a novel antimicrobial-containing adhesive system that would inhibit bacteria in the mouth and reduce secondary caries. The goal was to try and incorporate antimicrobial properties into total-etch and self-etch systems since both are used in clinical practice.
- The research project was composed of two experiments. The first one examined antimicrobial drugs inhibiting bacteria in the mouth. The second project examined ways of preventing caries recurrence.
- The team developed drug-silica particles which allowed them to overcome current challenges that antimicrobial systems right now have, namely the short term-effect or burst-release of the anti-microbial property as well as the compromising mechanical structure after the release of the antimicrobial drug.
- The team was able to show a long-term release of the antimicrobial and a bio degradation-triggered release, meaning that in the case of bacteria attack, there was an increase in the release of the drug with a greater effect when it was actually needed.